When God gives someone over to destruction, He hardens their hearts
Joshua 11:20
For it was of the Lord to harden their hearts, that they should come against Israel in battle, that He might utterly destroy them,
and that they might receive no
mercy, but that He might destroy them, as the Lord had commanded Moses.
Romans 1, describes this as God giving them over. If a man has been given over to destruction, this has come against their life from God.
And there are sins leading to death that John tells us not to pray for them. If God's wrath is on you, that is not a good thing for your life!
18 For the wrath of God is revealed from heaven against all ungodliness and unrighteousness of men, who [
d]suppress the truth in unrighteousness, 19 because what may be known of God is [
e]manifest [
f]in them, for God has shown
it to them. 20 For since the creation of the world His invisible
attributes are clearly seen, being understood by the things that are made,
even His eternal power and [
g]Godhead, so that they are without excuse, 21 because, although they knew God, they did not glorify
Him as God, nor were thankful, but became futile in their thoughts, and their foolish hearts were darkened. 22 Professing to be wise, they became fools, 23 and changed the glory of the incorruptible God into an image made like [
h]corruptible man—and birds and four-footed animals and creeping things.
24 Therefore God also gave them up to uncleanness, in the lusts of their hearts, to dishonor their bodies among themselves, 25 who exchanged the truth of God for the lie, and worshiped and served the creature rather than the Creator, who is blessed forever. Amen.
26 For this reason God gave them up to vile passions. For even their [
i]women exchanged the natural use for what is against nature. 27 Likewise also the [
j]men, leaving the natural use of the [
k]woman, burned in their lust for one another, men with men committing what is shameful, and receiving in themselves the penalty of their error which was due.
28 And even as they did not like to retain God in
their knowledge, God gave them over to a debased mind, to do those things which are not fitting; 29 being filled with all unrighteousness, [
l]sexual immorality, wickedness, [
m]covetousness, [
n]maliciousness; full of envy, murder, strife, deceit, evil-mindedness;
they are whisperers, 30 backbiters, haters of God, violent, proud, boasters, inventors of evil things, disobedient to parents, 31 [
o]undiscerning, untrustworthy, unloving, [
p]unforgiving, unmerciful; 32 who, knowing the righteous judgment of God, that those who practice such things are deserving of death, not only do the same but also approve of those who practice them.